Article: Promoter Hypermethylation Profiling Identifies Subtypes of Head and Neck Cancer with Distinct Viral, Environmental, Genetic and Survival Characteristics.
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Choudhury JH; Ghosh SK
PLoS ONE, 2015
10.1371/journal.pone.0129808.t003
Table 3 Frequency of DNA methylation of genes/loci and CIMP status analyzed in HPV (+) and HPV (-) HNSCC.
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Gene/loci
HPV positive (%)
HPV negative (%)
P -value*
DAPK
Methylated
16 (43.2)
5 (14.7)
Unmethylated
21 (56.8)
29 (85.3)
0.031
GSTP1
Methylated
16 (43.2)
6 (17.6)
Unmethylated
21 (56.8)
28 (82.4)
0.057
RASSF1
Methylated
25 (67.6)
11 (32.3)
Unmethylated
12 (32.4)
23 (67.7)
0.013
BRCA1
Methylated
10 (27.1)
3 (8.9)
Unmethylated
27 (72.9)
31 (91.1)
0.066
p16
Methylated
17 (45.9)
6 (17.6)
Unmethylated
20 (54.1)
28 (82.4)
0.031
ECAD
Methylated
16 (43.2)
7 (20.6)
Unmethylated
21 (56.8)
27 (79.4)
0.087
MINT1
Methylated
19 (51.3)
12 (35.3)
Unmethylated
18 (48.7)
22 (64.7)
0.522
MINT2
Methylated
20 (54.1)
17 (50)
Unmethylated
17 (45.9)
17 (50)
0.782
MINT31
Methylated
23 (62.2)
10 (29.4)
Unmethylated
14 (37.8)
24 (70.6)
0.015
MLH1
Methylated
3 (8.1)
1 (2.9)
Unmethylated
34 (91.9)
33 (97.1)
0.327
CIMP status
CIMP-negative
3 (8.1)
10 (29.4)
CIMP-low
13 (35.1)
17 (50)
0.477
CIMP-high
21 (56.8)
7 (20.6)
0.028
P trend
0.001
* Chi square test used to calculate P -value and further adjusting for age, gender, smoking, betel-quid and tobacco chewing status
P < 0.05 considered as statistically significant
Inferred neuron-electrophysiology data values
Neuron Type
Neuron Description
Ephys Prop
Extracted Value
Standardized Value
Content Source
